Register now for the WST CoP summer school on 18 July

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The workshops and creative sessions will be an opportunity not only to build skills and knowledge but will also be a chance to network with colleagues from across campus. Choose one of the three workshops below and register now. Content Overview: This workshop will give a fun, hands-on introduction to creative problem solving and why we need it more than ever to tackle the challenges of the 21st Century. We will explore Design Thinking which builds creative problem solving on the foundations of empathy for those affected, and insight into their underlying needs.

The method emphasises action over planning as a rapid way to test possible solutions and develop acceptable solutions via feedback and iteration.

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The clinical syndrome comprised of heart failure symptoms but with a left ventricular ejection fraction that is not diminished, e. It remains among the most challenging of clinical syndromes for the practicing clinician and scientist alike, with a multitude of proposed mechanisms involving the heart and other organs and complex interplay with common co-morbidities. Importantly, its morbidity and mortality is on par with heart failure and a reduced ejection fraction, and as the list of failed treatments continues to grow, HFpEF clearly represents a major unmet medical need.

The field is greatly in need of a more unified approach to its definition and view of the syndrome that engages integrative and reserve pathophysiology beyond that related to the heart alone. We need to reflect on prior treatment failures and the message this is providing, and re-direct our approaches likely with a paradigm shift in how the disease is viewed. Success will require interactions between clinicians, translational researchers, and basic physiologists.

Here, we review recent translational and clinical research into HFpEF, give perspectives on its evolving demographics and epidemiology, the role of multi-organ deficiencies, potential mechanisms that involve the heart and other organs, clinical trials, and future directions. Heart failure HF is a clinical syndrome characterized by breathlessness dyspnea at normal or low-level exertion, fatigue, and fluid retention. Given this, it is perhaps not surprising that we have yet to find an evidence-based HFpEF therapy beyond diuretics for fluid overload, and conventional treatments for co-morbidities.

In this article, we provide an overview of HFpEF for both the clinical and basic research scientist that includes a brief examination of its diagnostic criteria and evolving epidemiology, a summary of proposed mechanisms involving the heart and other organs, a discussion of our valiant but unsuccessful prior efforts to develop an effective therapy, and a review of newer potential approaches.

HFpEF is currently the accepted form and we stick to that here. The companion review in this issue by Loffredo et al.

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What happens if someone has some of these difficulties but not all? It can eliminate the worry that a person is severely mentally ill. Dating, with its unpredictable outcomes and unspoken language of social or Asperger Syndrome, you add on a whole new level of complexity. It can support the idea that the person has genuine difficulties arising from a real, legitimate condition.

A new, and more accurate, understanding of the person can lead to appreciation and respect for what the person is coping with. Acceptance by friends and family members is more likely. Employers are more likely to understand the ability and needs of an employee should that employee make the diagnosis known.

Accommodations can be requested and a rationale can be provided based on a known diagnosis. Having the diagnosis is a relief for many people. It provides a means of understanding why someone feels and thinks differently than others.

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